Sodium Carbonate → 5-(Bromomethyl)-3-(3-(difluoromethoxy)phenyl)-2-ethoxypyrazine

HRID 2271458Notes

Reaction equation

HRID 2271458 reaction equation
[F:1][CH:2]([F:20])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:11]([O:17][CH2:18][CH3:19])=[N:12][CH:13]=[C:14]([CH3:16])[N:15]=2)[CH:7]=[CH:8][CH:9]=1.[Br:21]C1C(OCC)=NC=C(C)N=1.B(O)O.C(=O)([O-])[O-].[Na+].[Na+]>CCO.C1(C)C=CC=CC=1.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[Br:21][CH2:16][C:14]1[N:15]=[C:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([O:3][CH:2]([F:1])[F:20])[CH:5]=2)[C:11]([O:17][CH2:18][CH3:19])=[N:12][CH:13]=1

Participants

8

Reactant 4

HCID 10340Sodium CarbonateHCID 61668Boronic AcidHCID 904146393-Bromo-2-ethoxy-5-methylpyrazineHCID 904155803-(3-(Difluoromethoxy)phenyl)-2-ethoxy-5-methylpyrazine

Product 1

HCID 904148165-(Bromomethyl)-3-(3-(difluoromethoxy)phenyl)-2-ethoxypyrazineYield 90%

Reagents, catalysts & solvents 3

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

3-(3-(Difluoromethoxy)phenyl)-2-ethoxy-5-methylpyrazine. A solution of 3-bromo-2-ethoxy-5-methylpyrazine (1.80 g, 8.29 mmol), 3-(difluoromethoxy)phenyl)boronic acid (2.03 g, 10.78 mmol), tetrakis(triphenylphosphine) palladium(0) (958.25 mg, 0.83 mmol), sodium carbonate (21.63 mL, 1.15 mol/L, 24.88 mmol), in EtOH (22 mL) and toluene (118 mL), under nitrogen, was heated at 88° C. for 1 h. The reaction mixture was extracted with EtOAc. The combined organic layers were dried (Na2SO4), and the solvent was removed under reduced pressure. Purification (FCC, SiO2, O-50%, EtOAc/hexanes) afforded the title compound as a colorless oil (2.09 g, 90%). [M+H]=281.19.

Workup

  1. extractionThe reaction mixture was extracted with EtOAc
  2. dry with materialThe combined organic layers were dried (Na2SO4)
  3. customthe solvent was removed under reduced pressure
  4. customPurification (FCC, SiO2

Sources & evidence

ORD record
ord-f036084617cc46a9aaaeeb968b94ed00
Source dataset
uspto-grants-2015_09
Patent number
US09120770B2

Reaction notes

Loading…