HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[Azido-(5-methylfuran-2-yl)methyl]tetrahydropyran → (5-Methylfuran-2-yl)(tetrahydro-2H-pyran-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[Azido-(5-methylfuran-2-yl)methyl]tetrahydropyran | HCID 89525435 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (5-Methylfuran-2-yl)(tetrahydro-2H-pyran-4-yl)methanamine | HCID 62907069 | 99.3% |
Reaction Steps
A solution of 3.09 g (14 mmol, 1 eq) of 4-[azido-(5-methylfuran-2-yl)methyl]tetrahydropyran in 60 ml of ethanol in the presence of 470 mg (15% by weight) of palladium on carbon at 10% was stirred at hydrogen atmospheric pressure for 17 hours. The reaction medium was filtered and the filtrate was evaporated. 2.715 g of C-(5-methylfuran-2-yl)-C-(tetrahydropyran-4-yl)methylamine were obtained. Yield=99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120772B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2faee2d9398044bb98899e9b0383666d |
| Source note | uspto-grants-2015_09 |