HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-hydroxy-N,N-dimethyl-3-nitrobenzamide → 3-Amino-2-hydroxy-N,N-dimethylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-hydroxy-N,N-dimethyl-3-nitrobenzamide | HCID 11367803 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-2-hydroxy-N,N-dimethylbenzamide | HCID 16098483 | 101% |
Reaction Steps
A solution of 33.5 g of 2-hydroxy-N,N-dimethyl-3-nitrobenzamide in 600 ml of ethanol were added to a suspension of 3.35 g of Pd/C 10% in 70 ml of ethanol. The reaction medium was stirred under 2 bar of hydrogen overnight. TLC and HPLC control (t=0.66 M+181). The reaction medium was filtered through celite and the filtrate was evaporated. 29 g of 3-amino-2-hydroxy-N,N-dimethylbenzamide were obtained in the form of an oily brown solid. Yield=100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120772B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-042c4481fb534245b01d6cc1291ab091 |
| Source note | uspto-grants-2015_09 |