反应详情

温度

130 °C

A stirred mixture of methyl 3-cyclopropyl-3-oxopropanoate (20 g, 0.141 mol), triethyl orthoformate (28 mL, 0.169 mol), and 4-bromoaniline (24.2 g, 0.141 mol) were heated at 130° C. for 5 h with a Dean Stark trap. After this time the reaction was cooled to room temperature, diluted with methylene chloride and filtered through a pad of silica. The filtrate was concentrated to afford the desired product (26.5 g, 55%) as a yellow solid: ESI MS m/z 324 [C14H14BrNO2+H]+.

1. temperatureAfter this time the reaction was cooled to room temperature
2. filtrationfiltered through a pad of silica
3. concentrationThe filtrate was concentrated