1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178504827, compound

HRID 2271516Notes

Reaction equation

HRID 2271516 reaction equation
C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1.[Br:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH:34]=[C:35]([S:41]([CH3:44])(=[O:43])=[O:42])[C:36]([O:38]CC)=O)=[CH:29][CH:28]=1>>[Br:26][C:27]1[CH:28]=[C:29]2[C:30](=[CH:31][CH:32]=1)[N:33]=[CH:34][C:35]([S:41]([CH3:44])(=[O:42])=[O:43])=[C:36]2[OH:38]

Participants

3

Reactant 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 66715339Ethyl 3-(4-bromophenylamino)-2-(methylsulfonyl)acrylate

Product 1

HCID 178504827HCID 178504827, compoundYield 61.2%

Procedure

To Dowtherm at 250° C. was added ethyl 3-(4-bromophenylamino)-2-(methylsulfonyl)acrylate (1.08 g, 3.10 mmol) portionwise and the reaction mixture was stirred for 2 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (573 mg, 61%) as a tan solid: ESI MS m/z 302 [C10H8BrNO3S+H]+.

Workup

  1. filtrationthe resulting precipitate was filtered

Sources & evidence

ORD record
ord-d834fe8378214a63ad5b29710e2f01bb
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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