1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178467072, compound

HRID 2271518Notes

Reaction equation

HRID 2271518 reaction equation
C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1.[Br:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH:34]=[C:35]([C:41](=[O:43])[CH3:42])[C:36]([O:38]CC)=O)=[CH:29][CH:28]=1>>[Br:26][C:27]1[CH:28]=[C:29]2[C:30](=[CH:31][CH:32]=1)[N:33]=[CH:34][C:35]([C:41](=[O:43])[CH3:42])=[C:36]2[OH:38]

Participants

3

Reactant 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 178471904HCID 178471904, compound

Product 1

HCID 178467072HCID 178467072, compoundYield 76%

Procedure

To Dowtherm at 250° C. was added Ethyl 2-[(4-bromophenylamino)methylene]-3-oxobutanoate (3.4 g, 10.9 mmol) portionwise and the reaction mixture was stirred for 1.5 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (2.2 g, 76%) as a brown solid: ESI MS m/z 266 [C11H8BrNO2+H]+.

Workup

  1. filtrationthe resulting precipitate was filtered

Sources & evidence

ORD record
ord-3a9b4bf344884e46b9ccf91626523e6d
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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