反应详情

To Dowtherm at 250° C. was added a solution of ethyl 2-[(4-bromophenylamino)methylene]-5-methyl-3-oxohexanoate (700 mg, 6.75 mmol) in Dowtherm (5 mL) portionwise and the reaction mixture was stirred for 1.5 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (490 mg, 23%) as a white solid: 1H NMR (500 MHz, DMSO-d6) δ 12.65 (s, 1H), 8.55 (d, J=6.4 Hz, 1H), 8.30 (d, J=2.3 Hz, 1H), 7.88 (dd, J=8.7, 2.3 Hz, 1H), 7.61 (d, J=8.8 Hz, 1H), 2.99 (d, J=6.8 Hz, 2H), 2.21-2.04 (m, 1H), 0.91 (d, J=6.7 Hz, 6H).

1. filtrationthe resulting precipitate was filtered