HCID 178471905, compound → HCID 178458757, compound

Participants

Reaction Conditions

Reaction Steps

Dowtherm A (200 mL) was heated to 240° C. Ethyl 2-(((4-bromophenyl)amino) methylene)-3-oxopentanoate (25.1 g, 77 mmol) was added portionwise. The reaction was then heated to 250° C. and stirred for 1.25 h. The reaction mixture was slowly cooled to room temperature and a precipitate formed. The suspension was diluted with hexanes (500 mL) and filtered to afford the desired product (15.9 g, 73%) as a tan solid: 1H NMR (300 MHz, DMSO-d6) δ 12.64 (br s, 1H), 8.56 (s, 1H), 8.30 (d, J=2.3 Hz, 1H), 7.88 (dd, J=8.8, 2.4 Hz, 1H), 7.61 (d, J=8.8 Hz, 1H), 3.10 (q, J=7.2 Hz, 2H), 1.05 (t, J=7.2 Hz, 3H).

Provenance & Evidence