HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenemethanamine, 4-amino-N,N-dimethyl- → 1-(6-Bromo-4-((4-((dimethylamino)methyl)phenyl)amino)quinolin-3-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenemethanamine, 4-amino-N,N-dimethyl- | HCID 308051 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-yl)propan-1-one | HCID 86692845 | — |
| Product | 1-(6-Bromo-4-((4-((dimethylamino)methyl)phenyl)amino)quinolin-3-yl)propan-1-one | HCID 68092137 | 86% |
Reaction Steps
Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)propan-1-one (750 mg, 2.51 mmol) was reacted with 4-(dimethylaminomethyl)aniline (377 mg, 2.51 mmol) to afford the desired product (889 mg, 86%) as a yellow solid. APCI MS m/z 412 [C21H22BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-01c53971b1124ab2966a49cbb0cb5f80 |
| Source note | uspto-grants-2015_09 |