1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-amine → 1-(6-bromo-4-((1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)quinolin-3-yl)ethanone

Participants

Role	Name	HCID	Charge
Reactant	1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-amine	HCID 53302346	—
Reactant	1-(6-Bromo-4-chloroquinolin-3-YL)ethanone	HCID 66715483	—
Product	1-(6-bromo-4-((1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)quinolin-3-yl)ethanone	HCID 66716084	52.1%

Reaction Steps

Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (285 mg, 1.0 mmol) was reacted with 1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-amine (0.30 g, 1.66 mmol) to afford the desired product (223 mg, 52%) as a light yellow solid. ESI MS m/z 428 [C20H22BrN5O+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09120749B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-f797d76638a8462c8b44b96ab6989276
Source note	uspto-grants-2015_09