HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Bromo-4-chloroquinolin-3-YL)ethanone → 1-(6-bromo-4-((1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)quinolin-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-YL)ethanone | HCID 66715483 | — |
| Reactant | 1-(1-Methyl-3-pyrrolidinyl)-1H-pyrazol-4-amine | HCID 67981641 | — |
| Product | 1-(6-bromo-4-((1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)quinolin-3-yl)ethanone | HCID 66716316 | 87% |
Reaction Steps
Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (285 mg, 1.0 mmol) was reacted with 1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-amine (0.28 g, 1.68 mmol) to afford the desired product (360 mg, 87%) as a light yellow solid. ESI MS m/z 414 [C19H20BrN5O+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-dac55086e63b49a785c25ad9e05ad27c |
| Source note | uspto-grants-2015_09 |