HCID 68091885, compound → HCID 178450271, compound

HRID 2271557Notes

Reaction equation

HRID 2271557 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:16])[CH2:13][CH2:14][CH3:15])=[C:5]2Cl.[NH2:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:16])[CH2:13][CH2:14][CH3:15])=[C:5]2[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:30])([CH3:29])[CH3:31])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 68091885HCID 68091885, compoundHCID 178419079HCID 178419079, compound

Product 1

HCID 178450271HCID 178450271, compoundYield 68%

Procedure

Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)butan-1-one (470 mg, 1.50 mmol) was reacted with tert-butyl (trans-4-aminocyclohexyl)carbamate (643 mg, 3 mmol) to afford the desired product (498 mg, 68%) as a light orange solid. ESI MS m/z 490 [C24H32BrN3O3+H]+

Sources & evidence

ORD record
ord-dbbe5a88f90b4ea7bc72b50c41e13dca
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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