Benzenemethanamine, 4-amino-N,N-dimethyl- → HCID 68091756, compound

HRID 2271558Notes

Reaction equation

HRID 2271558 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:16])[CH2:13][CH2:14][CH3:15])=[C:5]2Cl.[CH3:18][N:19]([CH2:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1)[CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:16])[CH2:13][CH2:14][CH3:15])=[C:5]2[NH:26][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][N:19]([CH3:20])[CH3:18])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 308051Benzenemethanamine, 4-amino-N,N-dimethyl-HCID 68091885HCID 68091885, compound

Product 1

HCID 68091756HCID 68091756, compoundYield 63%

Procedure

Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)butan-1-one (470 mg, 1.50 mmol) was reacted with 4-((dimethylamino)methyl)aniline (451 mg, 3 mmol) to afford the desired product (402 mg, 63%) as a yellow solid. ESI MS m/z 426 [C22H24BrN3O+H]+

Sources & evidence

ORD record
ord-740941e9c720419393a2925a707df111
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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