HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((Dimethylamino)methyl)aniline hydrochloride → 1-(6-Bromo-4-(4-((dimethylamino)methyl)phenylamino)quinolin-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((Dimethylamino)methyl)aniline hydrochloride | HCID 44891485 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-YL)ethanone | HCID 66715483 | — |
| Product | 1-(6-Bromo-4-(4-((dimethylamino)methyl)phenylamino)quinolin-3-yl)ethanone | HCID 66715798 | 70% |
Reaction Steps
Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (500 mg, 1.76 mmol) was reacted with 4-((dimethylamino)methyl)aniline hydrochloride (479 mg, 2.56 mmol) to afford the desired product (491 mg, 70%) as a yellow solid. ESI MS m/z 398 [C20H20BrN3O+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-93ecdf4c5be74d3bb903e029ba132a54 |
| Source note | uspto-grants-2015_09 |