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1,1-Dimethylethyl 4-(5-amino-2-pyrimidinyl)-1-piperazinecarboxylate → Tert-butyl 4-(5-((6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl)amino)pyrimidin-2-yl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Dimethylethyl 4-(5-amino-2-pyrimidinyl)-1-piperazinecarboxylate | HCID 59464319 | — |
| 反応物 | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| 生成物 | Tert-butyl 4-(5-((6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl)amino)pyrimidin-2-yl)piperazine-1-carboxylate | HCID 86692861 | 39% |
反応手順
Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1.0 mmol) was reacted with tert-butyl 4-(5-aminopyrimidin-2-yl)piperazine-1-carboxylate (419 mg, 1.5 mmol) to afford the desired product (215 mg, 39%) as a yellow solid. ESI MS m/z 553 [C26H29BrN6O3+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09120749B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-5304313f7d1648a4b518f789fdb974be |
| 出典メモ | uspto-grants-2015_09 |