HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate → tert-Butyl 8-[6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate | HCID 34178604 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | tert-Butyl 8-[6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate | HCID 66715811 | 73% |
Reaction Steps
Following general procedure B, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (200 mg, 0.640 mmol) was reacted with tert-butyl 2,8-diazaspiro[4,5]decane-2-carboxylate (169 mg, 0.704 mmol) to afford the desired product (240 mg, 73%) as a yellow foam: ESI MS m/z 514 [C26H32BrN3O3+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-67591f95c68e46609f7ff19ee7705a1b |
| Source note | uspto-grants-2015_09 |