4-Amino-1-methylpiperidine → HCID 66716363, compound

Participants

Reaction Steps

Following general procedure B, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (510 mg, 1.64 mmol) was reacted with 1-methylpiperidin-4-amine (375 mg, 3.28 mmol) to afford the desired product (552 mg, 87%) as a brown solid: 1H NMR (300 MHz, CD3OD) δ 9.12 (s, 1H), 8.38 (d, J=2.0 Hz, 1H), 7.84 (dd, J=8.9, 2.1 Hz, 1H), 7.79-7.71 (m, 1H), 4.20-3.97 (m, 1H), 2.93-2.69 (m, 3H), 2.47-2.19 (m, 5H), 2.19-2.03 (m, 2H), 1.86-1.60 (m, 2H), 1.32-1.16 (m, 2H), 1.16-1.00 (m, 2H).

Provenance & Evidence