HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-1,4-cyclohexanediamine → {6-Bromo-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-1,4-cyclohexanediamine | HCID 349884 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | {6-Bromo-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}(cyclopropyl)methanone | HCID 66716442 | 78% |
Reaction Steps
Following general procedure B, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (1.01 g, 3.25 mmol) was reacted with N1,N1-diethylcyclohexane-1,4-diamine (660 mg, 3.90 mmol) to afford the desired product (1.12 g, 78%) as a yellow wax: ESI MS m/z 523 [C23H30BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-7bb3bdeeb87e4fecb9e0944990d581b7 |
| Source note | uspto-grants-2015_09 |