反应详情

Following general procedure B, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (870 mg, 2.80 mmol) was reacted with trans-N1,N1-dimethylcyclohexane-1,4-diamine (400 mg, 2.80 mmol) to afford the desired product (398 mg, 36%) as a light yellow solid: 1H NMR (300 MHz, CD3OD) δ 9.12 (s, 1H), 8.41 (d, J=2.0 Hz, 1H), 7.85 (dd, J=8.9, 2.0 Hz, 1H), 7.76 (d, J=8.9 Hz, 1H), 4.10-3.84 (m, 1H), 2.93-2.70 (m, 1H), 2.56-2.40 (m, 1H), 2.37 (s, 6H), 2.25 (d, J=12.0 Hz, 2H), 2.05 (d, J=11.4 Hz, 2H), 1.62-1.31 (m, 4H), 1.31-1.01 (m, 4H).