(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone → HCID 178483663, compound

Participants

Reaction Steps

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (560 mg, 1.80 mmol) was reacted with trans-4-[(dimethylamino)methyl]cyclohexanamine (620 mg, 2.70 mmol) to afford the desired product (335 mg, 43%) as a yellow solid: 1H NMR (300 MHz, CD3OD) δ 9.12 (s, 1H), 8.41 (d, J=2.0 Hz, 1H), 7.84 (dd, J=8.9, 2.1 Hz, 1H), 7.75 (d, J=8.9 Hz, 1H), 4.12-3.84 (m, 1H), 2.91-2.72 (m, 1H), 2.42-2.26 (m, J=6.6 Hz, 8H), 2.21 (d, J=11.6 Hz, 2H), 1.94 (d, J=12.1 Hz, 2H), 1.75-1.59 (m, 1H), 1.59-1.35 (m, 2H), 1.25-0.98 (m, 6H).

Provenance & Evidence