Benzenemethanamine, 4-amino-N,N-dimethyl- → HCID 66715207, compound

HRID 2271586Notes

Reaction equation

HRID 2271586 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]([CH2:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1)[CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:26][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][N:19]([CH3:20])[CH3:18])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 308051Benzenemethanamine, 4-amino-N,N-dimethyl-HCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715207HCID 66715207, compoundYield 50%

Procedure

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (320 mg, 1.03 mmol) was reacted with 4-[(dimethylamino)methyl]aniline (210 mg, 1.54 mmol) to afford the desired product (218 mg, 50%) as a yellow solid: ESI MS m/z 425 [C22H22BrN3O+H]+.

Sources & evidence

ORD record
ord-e1b190f0cb514096a89418f09904d0f9
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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