HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrrolidin-1-ylmethyl)piperidine → 1-{6-Bromo-4-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]quinolin-3-yl}-2-methylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrrolidin-1-ylmethyl)piperidine | HCID 16768347 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-yl)-2-methylpropan-1-one | HCID 68091993 | — |
| Product | 1-{6-Bromo-4-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]quinolin-3-yl}-2-methylpropan-1-one | HCID 66716132 | 68.3% |
Reaction Steps
Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)-2-methylpropan-1-one (250 mg, 0.800 mmol) was reacted with 4-(pyrrolidin-1-ylmethyl)piperidine (168 mg, 1.00 mmol) to afford the desired product (243 mg, 68%) as a yellow solid: ESI MS m/z 444 [C23H30BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-624853bc9a764bbdb8d91587047c5e47 |
| Source note | uspto-grants-2015_09 |