N,N-dimethyl-1-(piperidin-4-yl)ethanamine → 1-{1-[6-Bromo-3-(methylsulfonyl)quinolin-4-yl]piperidin-4-yl}-N,N-dimethylethanamine

Participants

Reaction Steps

Following general procedure B, 6-bromo-4-chloro-3-(methylsulfonyl)quinoline (100 mg, 0.311 mmol) was reacted with N,N-dimethyl-1-(piperidin-4-yl)ethanamine (229 mg, 1.00 mmol) to afford the desired product (93 mg, 68%) as a white solid: 1H NMR (300 MHz, CDCl3) δ 9.24 (s, 1H), 8.50 (d, J=1.5 Hz, 1H), 8.11-7.93 (m, 2H), 3.67-3.55 (m, 2H), 3.44 (s, 3H), 3.34 (s, 2H), 2.75-2.62 (m, 1H), 2.46 (s, 6H), 2.07-1.96 (m, 1H), 1.90 (d, J=12.3 Hz, 2H), 1.73-1.53 (m, 2H), 1.15 (d, J=6.6 Hz, 3H).

Provenance & Evidence