4-(Pyrrolidin-1-ylmethyl)piperidine → HCID 66715820, compound

HRID 2271594Notes

Reaction equation

HRID 2271594 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[N:16]1([CH2:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH2:20][CH2:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[N:25]1[CH2:24][CH2:23][CH:22]([CH2:21][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 167683474-(Pyrrolidin-1-ylmethyl)piperidineHCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

Product 1

HCID 66715820HCID 66715820, compoundYield 80%

Procedure

Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (200 mg, 0.703 mmol) was reacted with 4-(pyrrolidin-1-ylmethyl)piperidine (168 mg, 1.00 mmol) to afford the desired product (233 mg, 80%) as a yellow solid: ESI MS m/z 416 [C21H26BrN3O+H]+.

Sources & evidence

ORD record
ord-a466791990cf4f5b846c01b814aa8732
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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