HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-1,4-cyclohexanediamine → 1-{6-Bromo-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-1,4-cyclohexanediamine | HCID 349884 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-YL)ethanone | HCID 66715483 | — |
| Product | 1-{6-Bromo-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}ethanone | HCID 66715793 | 92% |
Reaction Steps
Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (116 mg, 0.408 mmol) was reacted with N1,N1-diethylcyclohexane-1,4-diamine (138 mg, 0.812 mmol) to afford the desired product (157 mg, 51%) as an off-white solid: ESI MS m/z 418 [C21H28BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-33a45757fccb420c986007ffdc54ff93 |
| Source note | uspto-grants-2015_09 |