HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenemethanamine, 4-amino-N,N-dimethyl- → 1-(6-Bromo-4-(4-((dimethylamino)methyl)phenylamino)quinolin-3-yl)-2-methylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenemethanamine, 4-amino-N,N-dimethyl- | HCID 308051 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-yl)-2-methylpropan-1-one | HCID 68091993 | — |
| Product | 1-(6-Bromo-4-(4-((dimethylamino)methyl)phenylamino)quinolin-3-yl)-2-methylpropan-1-one | HCID 86692874 | 27.2% |
Reaction Steps
Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)-2-methylpropan-1-one (604 mg, 1.93 mmol) was reacted with 4-((dimethylamino)methyl)aniline (882 mg, 3.87 mmol) to afford the desired product (224 mg, 27%) as a yellow solid: ESI MS m/z 432, [C22H30BrN3O+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-45c94ae14afe413db65795109567d80e |
| Source note | uspto-grants-2015_09 |