HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-tert-butyl 1-(5-aminopyridin-2-yl)piperidin-3-ylcarbamate → (S)-tert-butyl 1-(5-(6-bromo-3-propionylquinolin-4-ylamino)pyridin-2-yl)piperidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-tert-butyl 1-(5-aminopyridin-2-yl)piperidin-3-ylcarbamate | HCID 66715841 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-yl)propan-1-one | HCID 86692845 | — |
| Product | (S)-tert-butyl 1-(5-(6-bromo-3-propionylquinolin-4-ylamino)pyridin-2-yl)piperidin-3-ylcarbamate | HCID 86692876 | 30% |
Reaction Steps
Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)propan-1-one (301 mg, 1.02 mmol) was reacted with (S)-tert-butyl 1-(5-aminopyridin-2-yl)piperidin-3-ylcarbamate (600 mg, 2.05 mmol) to obtain the desired product (168 mg, 30%) as an purple semi-solid.: ESI MS m/z 554 [C27H32BrN5O3+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-eae673bb348c4de8a47be4051ba79330 |
| Source note | uspto-grants-2015_09 |