HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitropyridine → 6-[3-(Dimethylamino)-1-pyrrolidinyl]-3-pyridinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| Product | 6-[3-(Dimethylamino)-1-pyrrolidinyl]-3-pyridinamine | HCID 21105670 | 56.3% |
Reaction Steps
Following General procedure H, 2-chloro-5-nitropyridine (500 mg, 3.1 mmol) was reacted with N,N-dimethylpyrrolidin-3-amine (400 mg, 3.5 mmol) followed by reduction to afford the desired product (360 mg, 56%) as a purple solid: ESI MS m/z 207 [C11H18N4+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b548e78a4b3b4be598b10e17046efe68 |
| Source note | uspto-grants-2015_09 |