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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2271633Generated: October 31, 2026

1-(5-Aminopyridin-2-yl)pyrrolidin-3-ol → (6-Bromo-4-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-ylamino)quinolin-3-yl)(cyclopropyl)methanone

https://huagongshe.com/reaction/2271633

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(5-Aminopyridin-2-yl)pyrrolidin-3-olHCID 53408167—
Reactant(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanoneHCID 66715111—
Product(6-Bromo-4-(6-(3-hydroxypyrrolidin-1-yl)pyridin-3-ylamino)quinolin-3-yl)(cyclopropyl)methanoneHCID 8669288551.6%

Reaction Steps

Following General procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1 mmol) was reacted with 1-(5-aminopyridin-2-yl)pyrrolidin-3-ol (269 mg, 1.5 mmol) to afford the desired product (234 mg, 51%) as a yellow solid: ESI MS m/z 453 [C22H21BrN4O2+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09120749B2
Source datasetuspto-grants-2015_09
ORD IDord-a291c53a360846ebbbfd4aaa7be822b3
Source noteuspto-grants-2015_09