HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(5-Aminopyridin-2-yl)amino]ethanol → (6-Bromo-4-(6-(2-hydroxyethylamino)pyridin-3-ylamino)quinolin-3-yl)(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(5-Aminopyridin-2-yl)amino]ethanol | HCID 3015333 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | (6-Bromo-4-(6-(2-hydroxyethylamino)pyridin-3-ylamino)quinolin-3-yl)(cyclopropyl)methanone | HCID 66715337 | 67.2% |
Reaction Steps
Following General procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1 mmol) was reacted with 2-(5-aminopyridin-2-ylamino)ethanol (230 mg, 1.5 mmol) to afford the desired product (287 mg, 67%) as a yellow solid: ESI MS m/z 427 [C20H19BrN4O2+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-72b68475ebe348bd817328c242b20796 |
| Source note | uspto-grants-2015_09 |