HuagongsheHuagongshe Chemistry Print Report · For research reference only
N2-(2-(dimethylamino)ethyl)pyridine-2,5-diamine → (6-Bromo-4-(6-(2-(dimethylamino)ethylamino)pyridine-3-ylamino)quinolin-3-yl)(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N2-(2-(dimethylamino)ethyl)pyridine-2,5-diamine | HCID 16772731 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | (6-Bromo-4-(6-(2-(dimethylamino)ethylamino)pyridine-3-ylamino)quinolin-3-yl)(cyclopropyl)methanone | HCID 66715789 | 66% |
Reaction Steps
Following General procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1 mmol) was reacted with N2-(2-(dimethylamino)ethyl)pyridine-2,5-diamine (270 mg, 1.5 mmol) to afford the desired product (300 mg, 66%) as a yellow solid: ESI MS m/z 454 [C22H24BrN5O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-8fba51da399d46b2a0fcfddd8af464cf |
| Source note | uspto-grants-2015_09 |