6-[2-(Dimethylamino)ethoxy]pyridin-3-amine → HCID 66715987, compound

HRID 2271637Notes

Reaction equation

HRID 2271637 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]([CH3:30])[CH2:20][CH2:21][O:22][C:23]1[N:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:29][C:26]1[CH:27]=[N:28][C:23]([O:22][CH2:21][CH2:20][N:19]([CH3:30])[CH3:18])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 206914066-[2-(Dimethylamino)ethoxy]pyridin-3-amineHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715987HCID 66715987, compoundYield 75%

Procedure

Following General procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1 mmol) was reacted with 6-(2-(dimethylamino)ethoxy)pyridin-3-amine (340 mg, 1.8 mmol) to afford the desired product (340 mg, 75%) as a yellow solid: ESI MS m/z 455 [C22H23BrN4O2+H]+.

Sources & evidence

ORD record
ord-f3a02a86b5144e20ba72b2e4a9ededd2
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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