3-amino-N,N-dimethylbenzylamine → HCID 66715475, compound

HRID 2271641Notes

Reaction equation

HRID 2271641 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]([CH2:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25])[CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:25][C:24]1[CH:26]=[CH:27][CH:28]=[C:22]([CH2:21][N:19]([CH3:20])[CH3:18])[CH:23]=1

Participants

3

Reactant 2

HCID 992943-amino-N,N-dimethylbenzylamineHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715475HCID 66715475, compoundYield 810%

Procedure

Following General procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (311 mg, 1 mmol) was reacted with 3-((dimethylamino)methyl)aniline (226 mg, 1.5 mmol) to afford the desired product (343 mg, 810%) as a yellow solid: ESI MS m/z 424 [C22H22BrN3O+H]+.

Sources & evidence

ORD record
ord-09bf2966fde9450e9f26e04555ac3800
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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