HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate → Tert-butyl 1-(5-(6-bromo-3-propionylquinolin-4-ylamino)pyridin-2-yl)pyrrolidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate | HCID 53470939 | — |
| Reactant | 1-(6-Bromo-4-chloroquinolin-3-yl)propan-1-one | HCID 86692845 | — |
| Product | Tert-butyl 1-(5-(6-bromo-3-propionylquinolin-4-ylamino)pyridin-2-yl)pyrrolidin-3-ylcarbamate | HCID 66716381 | 61.4% |
Reaction Steps
Following General procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)propan-1-one (298 mg, 1 mmol) was reacted with tert-butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate (439 mg, 1.5 mmol) to afford the desired product (332 mg, 61%) as a yellow solid: ESI MS m/z 540 [C26H30BrN5O3+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e2e56c50a6544a98a998c78591b76ccd |
| Source note | uspto-grants-2015_09 |