4-(2-Dimethylaminoethyl)aniline → HCID 66715989, compound

HRID 2271644Notes

Reaction equation

HRID 2271644 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[CH3:16][N:17]([CH3:27])[CH2:18][CH2:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[NH:24][C:23]1[CH:22]=[CH:21][C:20]([CH2:19][CH2:18][N:17]([CH3:16])[CH3:27])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 149398614-(2-Dimethylaminoethyl)anilineHCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

Product 1

HCID 66715989HCID 66715989, compoundYield 553.9%

Procedure

Following General procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (285 mg, 1 mmol) was reacted with 4-(2-(dimethylamino)ethyl)aniline (247 mg, 1.5 mmol) to afford the desired product (2284 mg, 55%) as a yellow solid: ESI MS m/z 412 [C21H22BrN3O+H]+.

Sources & evidence

ORD record
ord-884e98e33a744580951172ab37aa9929
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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