Potassium Carbonate → 3-Ethynyl-5-nitropyridine

참여 물질

반응 단계

To a solution of 3-nitro-5-((trimethylsilyl)ethynyl)pyridine (4.90 mmol) in MeOH (15 mL) was added K2CO3 (67 mg, 0.49 mmol). The mixture was stirred at rt for 30 min. The reaction mixture was diluted with ethyl acetate, washed with water and brine, dried over sodium sulfate, and chromatographed (hexane/ethyl acetate) to afford the desired product (540 mg, 74% over two steps) as a light brown solid: 1H NMR (300 MHz, CDCl3) δ 9.39-9.38 (m, 1H), 8.99-8.98 (m, 1H), 8.56-8.54 (m, 1H), 3.40 (s, 1H).

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