HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrrolidin-1-ylmethyl)aniline → {6-Bromo-4-[4-(pyrrolidin-1-ylmethyl)phenylamino]quinolin-3-yl}(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrrolidin-1-ylmethyl)aniline | HCID 776852 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | {6-Bromo-4-[4-(pyrrolidin-1-ylmethyl)phenylamino]quinolin-3-yl}(cyclopropyl)methanone | HCID 66715810 | 83.4% |
Reaction Steps
Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (320 mg, 1.03 mmol) was reacted 4-(pyrrolidin-1-ylmethyl)aniline (385 mg, 1.55 mmol) to afford the desired product (387 mg, 83%) as a yellow solid: ESI MS m/z 450 [C24H24BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-ceb2df8b45624848ba669f4b46c0e317 |
| Source note | uspto-grants-2015_09 |