HCID 58967078, compound → {6-Bromo-4-[6-(pyrrolidin-1-ylmethyl)pyridin-3-ylamino]quinolin-3-yl}(cyclopropyl)methanone

HRID 2271666Notes

Reaction equation

HRID 2271666 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[N:18]1([CH2:23][C:24]2[N:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:30][C:27]1[CH:28]=[N:29][C:24]([CH2:23][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 58967078HCID 58967078, compoundHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715896{6-Bromo-4-[6-(pyrrolidin-1-ylmethyl)pyridin-3-ylamino]quinolin-3-yl}(cyclopropyl)methanoneYield 78%

Procedure

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (310 mg, 1.00 mmol) was reacted with 6-(pyrrolidin-1-ylmethyl)pyridin-3-amine (280 mg, 1.50 mmol) to afford the desired product (352 mg, 78%) as a yellow foam: ESI MS m/z 451 [C23H23BrN4O+H]+.

Sources & evidence

ORD record
ord-9f6b7c5a371949259a678071e85e46c7
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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