883977-08-0 → HCID 66715828, compound

HRID 2271667Notes

Reaction equation

HRID 2271667 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]([CH3:29])[CH2:20][CH2:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:25][C:24]1[CH:26]=[CH:27][CH:28]=[C:22]([CH2:21][CH2:20][N:19]([CH3:18])[CH3:29])[CH:23]=1

Participants

3

Reactant 2

HCID 28720801883977-08-0HCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715828HCID 66715828, compoundYield 68%

Procedure

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (280 mg, 0.91 mmol) was reacted with 3-[2-(dimethylamino)ethyl]aniline (150 mg, 0.91 mmol) to afford the desired product (270 mg, 68%) as a yellow solid: ESI MS m/z 438 [C23H24BrN3O+H]+.

Sources & evidence

ORD record
ord-674561472643496b8e8180898ec1d577
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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