HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[2-(Pyrrolidin-1-yl)ethyl]aniline → (6-Bromo-4-(3-(2-(pyrrolidin-1-yl)ethyl)phenylamino)quinolin-3-yl)(cyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[2-(Pyrrolidin-1-yl)ethyl]aniline | HCID 21955022 | — |
| Reactant | (6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone | HCID 66715111 | — |
| Product | (6-Bromo-4-(3-(2-(pyrrolidin-1-yl)ethyl)phenylamino)quinolin-3-yl)(cyclopropyl)methanone | HCID 66715504 | 74.6% |
Reaction Steps
Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (197 mg, 0.635 mmol) was reacted with 3-[2-(pyrrolidin-1-yl)ethyl]aniline (120 mg, 0.635 mmol) to afford the desired product (220 mg, 74%) as a yellow solid: ESI MS m/z 464 [C25H26BrN3O+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1ffe27286509486e918ce4c3528f3daa |
| Source note | uspto-grants-2015_09 |