3-[2-(Pyrrolidin-1-yl)ethyl]aniline → HCID 86692895, compound

HRID 2271674Notes

Reaction equation

HRID 2271674 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[N:16]1([CH2:21][CH2:22][C:23]2[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=2)[NH2:26])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[NH:26][C:25]1[CH:27]=[CH:28][CH:29]=[C:23]([CH2:22][CH2:21][N:16]2[CH2:17][CH2:18][CH2:19][CH2:20]2)[CH:24]=1

Participants

3

Reactant 2

HCID 219550223-[2-(Pyrrolidin-1-yl)ethyl]anilineHCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

Product 1

HCID 86692895HCID 86692895, compoundYield 71.1%

Procedure

Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (180 mg, 0.635 mmol) was reacted with 3-[2-(pyrrolidin-1-yl)ethyl]aniline (120 mg, 0.635 mmol) to afford the desired product (198 mg, 71%) as a yellow solid: ESI MS m/z 438 [C23H24BrN3O+H]+.

Sources & evidence

ORD record
ord-466e0ce173e447518f21353b09bc6f45
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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