HCID 28720897, compound → HCID 66715722, compound

HRID 2271675Notes

Reaction equation

HRID 2271675 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]2[CH:28]=[C:29]([CH:31]=[CH:32][CH:33]=2)[NH2:30])[CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:30][C:29]1[CH:31]=[CH:32][CH:33]=[C:27]([CH2:26][CH2:25][N:22]2[CH2:21][CH2:20][N:19]([CH3:18])[CH2:24][CH2:23]2)[CH:28]=1

Participants

3

Reactant 2

HCID 28720897HCID 28720897, compoundHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 66715722HCID 66715722, compoundYield 55.8%

Procedure

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (240 mg, 0.77 mmol) was reacted with 3-(2-(4-methylpiperazin-1-yl)ethyl)aniline (170 mg, 0.77 mmol) to afford the desired product (212 mg, 55%) as a yellow solid: ESI MS m/z 493 [C26H29BrN4O+H]+.

Sources & evidence

ORD record
ord-9df32a07931649fa959c427b928f217f
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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