Trifluoroacetic acid → HCID 178511647, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl trans-4-[3-(cyclopropanecarbonyl)-6-(4-hydroxyphenyl)quinolin-4-ylamino]cyclohexylcarbamate (48 mg, 0.096 mmol) was reacted with TFA (0.40 mL) to afford the desired product (17.8 mg, 46%) as an off-white solid: 1H NMR (500 MHz, CD3OD) δ 9.16 (s, 1H), 8.37 (d, J=1.7 Hz, 1H), 8.07 (dd, J=8.7, 1.8 Hz, 1H), 7.92 (d, J=8.7 Hz, 1H), 7.60-7.56 (m, 2H), 6.96-6.92 (m, 2H), 4.29-4.19 (m, 1H), 3.29-3.20 (m, 1H), 2.89-2.80 (m, 1H), 2.37 (d, J=12.8 Hz, 2H), 2.18 (d, J=11.7 Hz, 2H), 1.75-1.64 (m, 2H), 1.64-1.53 (m, 2H), 1.23-1.18 (m, 2H), 1.15-1.09 (m, 2H); ESI MS m/z 402 [C25H27N3O2+H]+; HPLC 98.5% (AUC), tR=11.38 min.

Provenance & Evidence