Trifluoroacetic acid → HCID 178511644, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl trans-4-[6-(1H-benzo[d]imidazol-5-yl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]cyclohexylcarbamate (45.3 mg, 0.086 mmol) was reacted with TFA (2 mL) to afford the desired product (21.3 mg, 58%) as an off-white solid: 1H NMR (500 MHz, CDCl3) δ 9.16 (s, 1H), 8.48 (s, 1H), 8.27 (s, 1H), 8.12 (d, J=8.7 Hz, 1H), 7.99-7.93 (m, 2H), 7.74 (d, J=8.4 Hz, 1H), 7.67 (d, J=8.4 Hz, 1H), 4.29 (s, 1H), 3.17 (s, 1H), 2.93-2.78 (m, 1H), 2.36 (d, J=11.1 Hz, 2H), 2.15 (d, J=11.2 Hz, 2H), 1.72-1.53 (m, 4H), 1.23-1.17 (m, 2H), 1.14-1.05 (m, 2H); ESI MS m/z 426 [C26H27N5O+H]+; HPLC 96.0% (AUC), tR=8.89 min.

Provenance & Evidence