Trifluoroacetic acid → HCID 68091919, compound

Participants

Reaction Steps

Following general procedure A-2, tert-butyl 4-{2-[6-(3-Chloro-4-hydroxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]ethyl}piperazine-1-carboxylate (40 mg, 0.073 mmol) was reacted with TFA (2 mL) to afford the desired product (23 mg, 35%) as a yellow solid: 1H NMR (500 MHz, DMSO-d6) δ 10.00 (s, 1H), 9.09 (s, 1H), 8.46 (d, J=1.8 Hz, 1H), 7.98 (dd, J=8.7, 1.9 Hz, 1H), 7.85 (d, J=8.7 Hz, 1H), 7.78 (d, J=2.3 Hz, 1H), 7.61 (dd, J=8.5, 2.3 Hz, 1H), 7.09 (d, J=8.4 Hz, 1H), 3.82 (d, J=5.2 Hz, 2H), 2.95-2.82 (m, 1H), 2.68 (t, J=4.7 Hz, 4H), 2.55 (t, J=6.0 Hz, 2H), 2.35 (s, 4H), 1.11-0.97 (m, 4H); ESI MS m/z 451 [C25H27ClN4O2+H]+; HPLC>99% (AUC), tR=9.32 min.

Provenance & Evidence