2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 66715476, compound

Participants

Reaction Steps

Following general procedure F, (6-bromo-4-{4-[(dimethylamino)methyl]phenylamino}quinolin-3-yl)(cyclopropyl)methanone (44 mg, 0.104 mmol) was reacted with 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (45 mg, 0.156 mmol) to afford the desired product (38 mg, 73%) as a yellow solid: 1H NMR (300 MHz, CD3OD+Acetic Acid-d4) δ 9.26 (s, 1H), 7.99 (d, J=10.0 Hz, 2H), 7.94 (s, 1H), 7.51 (d, J=8.4 Hz, 2H), 7.29 (s, J=9.9 Hz, 3H), 7.25 (s, 1H), 4.32 (s, 2H), 2.94-2.85 (m, 1H), 2.82 (s, 6H), 1.17-1.01 (m, 4H); ESI MS m/z 506 [C28H25Cl2N3O2+H]+; HPLC 94.4% (AUC), tR=11.19 min.

Provenance & Evidence