Trifluoroacetic acid → HCID 66715465, compound

Participants

Reaction Steps

Following procedure A-2 tert-butyl 4-(5-(3-acetyl-6-(3-chloro-5-fluoro-4-hydroxyphenyl)quinolin-4-ylamino)pyrimidin-2-yl)piperazine-1-carboxylate (50 mg, 0.084 mmol) was treated with TFA (2 mL) to afford the desired product (11 mg, 26%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 9.29 (s, 1H), 8.55 (s, 2H), 8.23 (dd, J=11, 2 Hz, 1H), 8.02 (m, 2H), 7.12 (m, 2H), 4.21 (t, J=10 Hz, 4H), 3.35 (t, J=10.5 Hz, 4H) 2.80 (s, 3H); ESI MS m/z 493, [C25H22ClFN6O2+H]+; HPLC 99.0% (AUC), tR=9.90 min.

Provenance & Evidence