2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 66716046, compound

Participants

Reaction Steps

Following general procedure D, (6-bromo-4-(4-(3-methoxypyrrolidin-1-yl)cyclohexylamino)quinolin-3-yl)(cyclopropyl)methanone (60 mg, 0.13 mmol) was reacted with 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (55 mg, 0.19 mmol) to afford the desired product (46 mg, 64%) as a brown solid: 1H NMR 1H NMR (500 MHz, MeOD+TFA-d) δ 9.42 (s, 1H), 8.46 (s, 1H), 8.31-8.23 (m, 1H), 8.04-7.97 (m, 1H), 7.75 (s, 1H), 7.71 (s, 1H), 4.99 (br s, 1H), 4.23-4.14 (m, 1H), 3.82-3.61 (m, 2H), 3.43-3.30 (m, 6H), 3.27-3.19 (m, 1H), 2.93-2.82 (m, 1H), 2.60-2.03 (m, 7H), 2.02-1.61 (m, 3H), 1.37-1.18 (m, 4H).; ESI MS m/z 554 [C30H33Cl2N3O3+H]+; HPLC>99.0% (AUC), tR=10.97 min.

Provenance & Evidence