HCID 66715402, compound → HCID 66715709, compound

Participants

Reaction Steps

Following general procedure D, 1-(6-bromo-4-(6-(2-(dimethylamino)ethylamino)pyridine-3-ylamino)quinolin-3-yl)ethanone (100 mg, 0.23 mmol) was reacted with 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (82 mg, 0.35 mmol) to afford the desired product (18 mg, 16%) as a green-yellow solid: 1H NMR (500 MHz, CD3OD+TFA-d) δ 9.29 (s, 1H), 8.26-8.20 (m, 2H), 8.05-7.99 (m, 2H), 7.69 (dd, J=9.0, 2.7 Hz, 1H), 7.18-7.07 (m, 2H), 6.96 (d, J=9.0 Hz, 1H), 3.89-3.83 (m, 2H), 3.46-3.37 (m, 2H), 2.96 (s, 6H), 2.80 (s, 3H); ESI MS m/z 494 [C26H25ClFN5O2+H]+; HPLC 97.2% (AUC), tR=10.46 min.

Provenance & Evidence