HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 86692990, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 66716079 | — |
| Reactant | HCID 86692892 | HCID 86692892 | — |
| Product | HCID 86692990 | HCID 86692990 | 73.9% |
Reaction Steps
Following general procedure F, tert-butyl 4-[5-(6-bromo-3-butyrylquinolin-4-ylamino)pyridin-2-yl]piperazine-1-carboxylate (80 mg, 0.144 mmol) was reacted with 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (59 mg, 0.216 mmol) to afford the crude product (66 mg) as an orange solid: ESI MS m/z 620 [C33H35ClFN5O4+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fe69e91f8aab4dbb9b9bb2e97208943f |
| Source note | uspto-grants-2015_09 |